Allylglycine is a glycine derivative. It is an inhibitor of glutamate decarboxylase[1]re and an antagonist of gamma-aminobutyric acid (GABA).[2]
It inhibits the synthesis of GABA.[3]
It is used to induce convulsions in experimental animals.
References
- ^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology. 27 (11): 1171–7. PMID 3205383.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Allylglycine, PubChem
- ^ Sajdyk T, Johnson P, Fitz S, Shekhar A (2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford). 22 (6): 633–41. doi:10.1177/0269881107082902. PMID 18308797.
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