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'''Allylglycine''' is a [[glycine]] derivative. It is an inhibitor of the [[enzyme]] [[glutamate decarboxylase]].<ref name="pmid3205383">{{cite journal | |
'''Allylglycine''' is a [[glycine]] derivative. It is an inhibitor of the [[enzyme]] [[glutamate decarboxylase]].<ref name="pmid3205383">{{cite journal |vauthors =Abshire VM, Hankins KD, Roehr KE, DiMicco JA |title=Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate |journal=Neuropharmacology |volume=27 |issue=11 |pages=1171–7 |date=November 1988 |pmid=3205383 |doi= 10.1016/0028-3908(88)90013-5|url= }}</ref> Inhibition of glutamate decarboxylase blocks [[GABA]] [[biosynthesis]], leading to lower levels of the [[neurotransmitter]].<ref name="pmid18308797">{{cite journal |vauthors =Sajdyk T, Johnson P, Fitz S, Shekhar A |title=Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior |journal=J. Psychopharmacol. (Oxford) |volume=22 |issue=6 |pages=633–41 |date=August 2008 |pmid=18308797 |doi=10.1177/0269881107082902 |url=http://jop.sagepub.com/cgi/pmidlookup?view=long&pmid=18308797 |pmc=3065212}}</ref> Allylglycine is known to induce [[seizure]]s in animals studies, presumably due to this GDC-inhibiting activity.<ref name="pmid1654571">{{cite journal |vauthors =Thomas J, Yang YC |title=Allylglycine induced seizures in male and female rats |journal=Physiol Behav. |volume=49 |issue=6 |pages=1181–3 |date=June 1991 |pmid=1654571 |url=http://www.ncbi.nlm.nih.gov/pubmed/1654571}}</ref> |
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==References== |
==References== |
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{{Reflist|2}} |
{{Reflist|2}} |
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{{GABAergics}} |
{{GABAergics}} |
Revision as of 15:24, 20 May 2016
Names | |
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IUPAC name
2-Aminopent-4-enoic acid
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.028.809 |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C5H9NO2 | |
Molar mass | 115.13 g/mol |
Appearance | white crystalline powder |
Density | 1.098 g/mL |
Melting point | 265 °C (509 °F; 538 K) |
Boiling point | 231 °C (448 °F; 504 K) |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Irritant |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Allylglycine is a glycine derivative. It is an inhibitor of the enzyme glutamate decarboxylase.[1] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.[2] Allylglycine is known to induce seizures in animals studies, presumably due to this GDC-inhibiting activity.[3]
References
- ^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (November 1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology. 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383.
- ^ Sajdyk T, Johnson P, Fitz S, Shekhar A (August 2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford). 22 (6): 633–41. doi:10.1177/0269881107082902. PMC 3065212. PMID 18308797.
- ^ Thomas J, Yang YC (June 1991). "Allylglycine induced seizures in male and female rats". Physiol Behav. 49 (6): 1181–3. PMID 1654571.