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'''Allylglycine''' is a [[glycine]] derivative. It is an inhibitor of the [[enzyme]] [[glutamate decarboxylase]].<ref name="pmid3205383">{{cite journal |author=Abshire VM, Hankins KD, Roehr KE, DiMicco JA |title=Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate |journal=Neuropharmacology |volume=27 |issue=11 |pages=1171–7 |year=1988 |month=November |pmid=3205383 |doi= 10.1016/0028-3908(88)90013-5|url=}}</ref> Inhibition of glutamate decarboxylase blocks [[GABA]] [[biosynthesis]], leading to lower levels of the [[neurotransmitter]].<ref name="pmid18308797">{{cite journal |author=Sajdyk T, Johnson P, Fitz S, Shekhar A |title=Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior |journal=J. Psychopharmacol. (Oxford) |volume=22 |issue=6 |pages=633–41 |year=2008 |month=August |pmid=18308797 |doi=10.1177/0269881107082902 |url=http://jop.sagepub.com/cgi/pmidlookup?view=long&pmid=18308797}}</ref> It is used to induce [[convulsion]]s in animals in scientific studies.{{fact|date=September 2011}} |
'''Allylglycine''' is a [[glycine]] derivative. It is an inhibitor of the [[enzyme]] [[glutamate decarboxylase]].<ref name="pmid3205383">{{cite journal |author=Abshire VM, Hankins KD, Roehr KE, DiMicco JA |title=Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate |journal=Neuropharmacology |volume=27 |issue=11 |pages=1171–7 |year=1988 |month=November |pmid=3205383 |doi= 10.1016/0028-3908(88)90013-5|url=}}</ref> Inhibition of glutamate decarboxylase blocks [[GABA]] [[biosynthesis]], leading to lower levels of the [[neurotransmitter]].<ref name="pmid18308797">{{cite journal |author=Sajdyk T, Johnson P, Fitz S, Shekhar A |title=Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior |journal=J. Psychopharmacol. (Oxford) |volume=22 |issue=6 |pages=633–41 |year=2008 |month=August |pmid=18308797 |doi=10.1177/0269881107082902 |url=http://jop.sagepub.com/cgi/pmidlookup?view=long&pmid=18308797}}</ref> It is used to induce [[convulsion]]s in animals in scientific studies.{{fact|date=September 2011}} |
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==References== |
==References== |
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[[Category:Amino acids]] |
[[Category:Amino acids]] |
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[[Category:Convulsants]] |
[[Category:Convulsants]] |
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Revision as of 18:52, 10 September 2011
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| Names | |
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| IUPAC name
2-Aminopent-4-enoic acid
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.028.809 |
PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C5H9NO2 | |
| Molar mass | 115.13 g/mol |
| Melting point | 265 °C (509 °F; 538 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Allylglycine is a glycine derivative. It is an inhibitor of the enzyme glutamate decarboxylase.[1] Inhibition of glutamate decarboxylase blocks GABA biosynthesis, leading to lower levels of the neurotransmitter.[2] It is used to induce convulsions in animals in scientific studies.[citation needed]
References
- ^ Abshire VM, Hankins KD, Roehr KE, DiMicco JA (1988). "Injection of L-allylglycine into the posterior hypothalamus in rats causes decreases in local GABA which correlate with increases in heart rate". Neuropharmacology. 27 (11): 1171–7. doi:10.1016/0028-3908(88)90013-5. PMID 3205383.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Sajdyk T, Johnson P, Fitz S, Shekhar A (2008). "Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behavior". J. Psychopharmacol. (Oxford). 22 (6): 633–41. doi:10.1177/0269881107082902. PMID 18308797.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)