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Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: ChemSpiderID InChI InChIKey SMILES1. |
Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: StdInChI StdInChIKey. |
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| InChIKey = HWXBTNAVRSUOJR-UHFFFAOYAI |
| InChIKey = HWXBTNAVRSUOJR-UHFFFAOYAI |
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| SMILES1 = O=C(O)C(O)CCC(=O)O |
| SMILES1 = O=C(O)C(O)CCC(=O)O |
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| StdInChI = 1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10) |
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| StdInChIKey = HWXBTNAVRSUOJR-UHFFFAOYSA-N |
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| CASNo=2889-31-8 |
| CASNo=2889-31-8 |
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| PubChem=43 |
| PubChem=43 |
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Revision as of 10:50, 29 November 2010
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| Names | |
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| IUPAC name
2-Hydroxypentanedioic acid
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| MeSH | Alpha-hydroxyglutarate |
PubChem CID
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| Properties | |
| C5H8O5 | |
| Molar mass | 148.11 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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alpha-Hydroxyglutaric acid is a alpha hydroxy acid.
alpha-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a Hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to alpha-Ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-Hydroxyglutaric aciduria.