chemokine (C-C motif) ligand 14 | |||||||
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Identifiers | |||||||
Symbol | CCL14 | ||||||
Alt. symbols | SCYA14, HCC-1, HCC-3, NCC-2, SCYL2, CKb1, MCIF | ||||||
NCBI gene | 6358 | ||||||
HGNC | 10612 | ||||||
OMIM | 601392 | ||||||
RefSeq | NM_032962 | ||||||
UniProt | Q16627 | ||||||
Other data | |||||||
Locus | Chr. 17 q11.2 | ||||||
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Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.[1] CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.[2]
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