As a nickname, The Snake or Snake may refer to:

• Phil Baker (footballer) (born 1952), former Australian rules footballer
• Nate Bowman (1943–1984), American Basketball Association and National Basketball Association player
• Kevin Durant (born 1988), National Basketball Association player
• Barry Fry (curler) (1939–2021), Canadian curler
• Nate Jones (boxer) (born 1972), American former Olympic and professional boxer
• Milan Jovanović (footballer, born 1981), Serbian former footballer
• Marco McDonald (born 1977), Jamaican footballer
• Ken Norman (born 1964), American retired National Basketball Association player
• Sino Nyoka (born 1990), South African rugby union player
• Jacques Plante (1929–1986), Canadian Hall-of-Fame National Hockey League goaltender
• Jake Plummer (born 1974), American retired National Football League quarterback
• Don Prudhomme (born 1941), American drag racer
• Jerry Scanlan (1957–2015), American former football player
• James Silas (born 1949), retired American Basketball Association and National Basketball Association player
• Ken Stabler (1945–2015), American retired National Football League quarterback
• Tom Sturdivant (1930–2009), American Major League Baseball pitcher
• Snake Wiltse (1871–1928), American Major League Baseball pitcher

• Thomas Kinney (1868–1912), Missouri state senator and gangster
• Carmine Persico (1933–2019), boss of the Colombo crime family in New York City

• Dennis Chalker (born 1954), American retired US Navy SEAL, inventor and author
• Joseph Cheesman Thompson (1874–1943), US Navy medical officer and polymath
• Bruce P. Crandall (born 1933), retired US Army soldier awarded the Medal of Honor

• All pages with titles beginning with The Snake
• All pages with titles containing The Snake
• Sergio Mora (born 1980), Mexican-American former world champion boxer nicknamed "The Latin Snake"
• Donnie Nietes (born 1982), Filipino world champion boxer nicknamed "Ahas" (Tagalog for "Snake")