| tRNA (adenine-N1-)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.36 | ||||||||
| CAS no. | 37257-03-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a tRNA (adenine-N1-)-methyltransferase (EC 2.1.1.36) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + tRNA S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine
Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methyladenine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate adenine 1-methyltransferase, transfer RNA (adenine-1) methyltransferase, 1-methyladenine transfer RNA methyltransferase, adenine-1-methylase, and S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase.
References[edit]
- Baguley BC, Staehelin M (1968). "The specificity of transfer ribonucleic acid methylases from rat liver". Biochemistry. 7 (1): 45–50. doi:10.1021/bi00841a007. PMID 4921283.
- Bjork GR, Svensson I (1969). "Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae". Eur. J. Biochem. 9 (2): 207–15. doi:10.1111/j.1432-1033.1969.tb00596.x. PMID 4896260.
- Dubois EG, Dirheimer G, Weil JH (1974). "Methylation of yeast tRNA Asp by enzymes from cytoplasm, chloroplasts and mitochondria of phaseolus vulgaris". Biochim. Biophys. Acta. 374 (3): 332–41. doi:10.1016/0005-2787(74)90254-8. PMID 4611497.
- Glick JM, Leboy PS (1977). "Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver". J. Biol. Chem. 252 (14): 4790–5. PMID 17605.
