Trinucleotide repeat-containing gene 6A protein is a protein that in humans is encoded by the TNRC6Agene.[5][6]
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA (Jul 1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum Genet. 100 (1): 114–22. doi:10.1007/s004390050476. PMID9225980. S2CID25999127.
Eystathioy T, Chan EK, Mahler M, et al. (2004). "A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182". Hybrid. Hybridomics. 22 (2): 79–86. doi:10.1089/153685903321947996. PMID12831532.
Eystathioy T, Chan EK, Takeuchi K, et al. (2004). "Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182". J. Mol. Med. 81 (12): 811–818. doi:10.1007/s00109-003-0495-y. PMID14598044. S2CID31604559.