The stratosphere is a region of Earth's upper atmosphere.

Stratosphere may also refer to:

• Stratosphere: Conquest of the Skies, a 1998 computer game
• "Stratosphere gun", nickname for the U.S. Army 120 mm M1 gun
• Stratosphere Las Vegas, a casino hotel in Las Vegas, Nevada
• Suzuki Stratosphere, a concept motorcycle

• Stratosphere Sound, a recording studio in New York City
• Stratosfear, a 1976 album by Tangerine Dream
• Stratosphere (Duster album), 1998
• Stratosphere (Matt Sorum album), 2014
• "Stratosphere", a song by Stratovarius