The surname Petrus may refer to:

• Annick Petrus (born 1961), French Saint Martinois politician
• Brent Petrus (born 1975), American football player
• Jacques Fred Petrus (1948–1987), French-Italian business man
• Junauda Petrus (born 1981), American author and performance artist
• Lars Petrus (born 1960), Swedish speedcuber and inventor of the Petrus method
• Mitch Petrus (1987–2019), American football player