Main is a surname. People with it include:
- Alan Main, Scottish football goalkeeper
- Alexander H. Main. American politician
- Anne Main, British politician
- Bert Main, Australian zoologist
- Charles T. Main, American engineer
- Frank Main (born 1964), American journalist
- George Washington Main (1807–1836) Alamo defender
- George Main (horse racing) (1879–1948), Australian pastoralist and horse breeder, chairman of the Australian Jockey Club
- Grant Main, Canadian rower
- Jack Main (John Alfred Main 1876–1945), Australian rules footballer
- James Main, Scottish football player
- John Main, British Benedictine monk
- Marjorie Main, American actress
- Oliver Main, member of the Pigeon Detectives
- Robert Main, British astronomer
- Sandy Main, Scottish football player
- Terence Main (born 1954), American modernist sculptor
- Willett Main, American politician