Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2gene.[5][6][7]
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.[7]
Ide N, Hata Y, Deguchi M, et al. (1999). "Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin". Biochem. Biophys. Res. Commun. 256 (3): 456–61. doi:10.1006/bbrc.1999.0364. PMID10080919.
Franklin JL, Yoshiura K, Dempsey PJ, et al. (2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein". Exp. Cell Res. 303 (2): 457–70. doi:10.1016/j.yexcr.2004.10.007. PMID15652357.
Hu Y, Li Z, Guo L, et al. (2007). "MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells". Arch. Biochem. Biophys. 467 (1): 1–9. doi:10.1016/j.abb.2007.07.027. PMID17880912.
PDB gallery
1uep: Solution Structure of the third PDZ domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 Protein)
1ueq: Solution Structure of the first PDZ domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 protein)
1uew: Solution Structure of the fourth PDZ domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 Protein)
1ujv: Solution structure of the second PDZ domain of human membrane associated guanylate kinase inverted-2 (MAGI-2)
1wfv: Solution structure of the fifth PDZ domain of human membrane associated guanylate kinase inverted-2 (KIAA0705 protein)