Méndez Núñez or Mendez-Nuñez may refer to:
- Mendez, Cavite, officially the Municipality of Mendez-Nuñez, a fourth-class urban municipality in the province of Cavite, Philippines
- Casto Méndez Núñez (1824–1869), Spanish naval officer
- Spanish ironclad Méndez Núñez, a wooden-hulled armored frigate
- Spanish cruiser Méndez Núñez, a Blas de Lezo-class cruiser
- Spanish destroyer Mendez Nunez (D63), a Gearing-class destroyer, former USS O'Hare (DD-889)
- Spanish frigate Méndez Núñez (F104), an Álvaro de Bazán-class frigate