Grasso is a surname, and may refer to:

• Alexa Grasso (born 1993), Mexican mixed martial artist
• Dick Ibarra Grasso (1914–2000), Argentine researcher
• Domenico Grasso (born 1955), American engineer and educator
• Ella Grasso (1919–1981), American politician
• Francis Grasso (1949–2001), American disc jockey
• Mateo Grasso (born 1995), Argentine professional footballer
• Pietro Grasso (born 1945), Italian politician
• Richard Grasso (born 1946), chairman and chief executive of the New York Stock Exchange
• Thomas J. Grasso (1962–1995), American double murderer executed by lethal injection
• Andrew Grasso (born 1997), American drummer for Gayle (singer)

• Mistralian norm for Grasse