Depaul, de Paul or DePaul may refer to:

• Andy DePaul (1928–2014), American amateur and professional boxer and referee
• Bobby DePaul (born 1963), American football coach
• Fernando de Paul (born 1991), Argentine footballer
• Gene de Paul (1919–1988), American pianist, composer and songwriter
• Katherine DePaul (born 1972), American artist manager
• Lyndsay DePaul (born 1988), American swimmer
• Lynsey de Paul (1950–2014), English singer-songwriter
• Rodrigo De Paul (born 1994), Argentine footballer
• Steven DePaul, American television director and producer
• Tony DePaul, American comic writer
• Vincent de Paul (1581–1660), Catholic priest and saint
• Vincent De Paul (actor) (born 1960), American actor and model
• William de Paul, 14th century English Carmelite and bishop of Meath in Ireland

• De Paula