The Brachyspira holin (B-Hol) Family (TC# 1.E.55) consists of several proteins from the GTA holin of Brachyspira hyodysenteriae (TC# 1.E.55.1.1), which facilitates gene transfer agent-release (see also GTA holin family) to VSH-1 holin of Brachyspira pilosicoli. VSH-1 is thought to participate in cell lysis. These proteins range in size from about 85 to 145 amino acyl residues (aas) and exhibit between 2 and 4 transmembrane segments (TMSs). A representative list of proteins belonging to the B-Hol family can be found in the Transporter Classification Database.^[1]

See also[edit]

• Holin
• Lysin
• Transporter Classification Database

Further reading[edit]

• Matson, Eric G.; Thompson, M. Greg; Humphrey, Samuel B.; Zuerner, Richard L.; Stanton, Thad B. (2005-09-01). "Identification of genes of VSH-1, a prophage-like gene transfer agent of Brachyspira hyodysenteriae". Journal of Bacteriology 187 (17): 5885–5892. doi:10.1128/JB.187.17.5885-5892.2005. ISSN 0021-9193. PMC 1196157. PMID 16109929.
• Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191.
• Saier, Milton H.; Reddy, Bhaskara L. (2015-01-01). "Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications". Journal of Bacteriology 197(1): 7–17. doi:10.1128/JB.02046-14. ISSN 0021-9193. PMC 4288690. PMID 25157079.
• Wang, I. N.; Smith, D. L.; Young, R. (2000-01-01). "Holins: the protein clocks of bacteriophage infections". Annual Review of Microbiology 54: 799–825. doi:10.1146/annurev.micro.54.1.799. ISSN 0066-4227. PMID 11018145.

References[edit]

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