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The Spanish missions in the Carolinas were part of a series of religious outposts established by Spanish Catholics in order to spread the Christian doctrine among the local Native Americans. A few missions to native people living in the vicinity of the Spanish presidio at Santa Elena (on Parris Island) in South Carolina were established from 1566 to 1570, including:

• Escamau-Orista,^[1]
• Guatari,^[2] and
• Joadi.^[3]

• Sebastián Montero

• Hann, John H. (April 1990). "Summary Guide to Spanish Florida Missions and Visitas. With Churches in the Sixteenth and Seventeenth Centuries". The Americas. 46 (4): 417–513. doi:10.2307/1006866. JSTOR 1006866. S2CID 147329347.