Protein-coding gene in the species Homo sapiens
Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene .
[ 5] Fasudil is an inhibitor of ROCK protein.
The protein encoded by this gene is a serine /threonine kinase that regulates cytokinesis , smooth muscle contraction, the formation of actin stress fibers and focal adhesions , and the activation of the c-fos serum response element . This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho .
Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry . 41 (28): 8948–53. doi :10.1021/bi0258243 . PMID 12102637 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
Overview of all the structural information available in the PDB for UniProt : O75116 (Human Rho-associated protein kinase 2 (ROCK2)) at the PDBe-KB .