Protein-coding gene in the species Homo sapiens
Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene .[5] [6] [7]
Function [ edit ]
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[7]
Interactive pathway map [ edit ]
Click on genes, proteins and metabolites below to visit related articles. [§ 1]
[[File:
|alt=MECP2 and associated Rett Syndrome
edit ]]
MECP2 and associated Rett Syndrome
edit
^ The interactive pathway map can be edited at WikiPathways: "WP3584" .
Interactions [ edit ]
MYT1 has been shown to interact with PIN1 .[8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000196132 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010505 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kim JG, Hudson LD (December 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene" . Molecular and Cellular Biology . 12 (12): 5632–9. doi :10.1128/mcb.12.12.5632 . PMC 360502 . PMID 1280325 .
^ Booher RN, Holman PS, Fattaey A (August 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity" . The Journal of Biological Chemistry . 272 (35): 22300–6. doi :10.1074/jbc.272.35.22300 . PMID 9268380 .
^ a b "Entrez Gene: MYT1 myelin transcription factor 1" .
^ Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science . 112 (19): 3361–71. doi :10.1242/jcs.112.19.3361 . PMID 10504341 .
Further reading [ edit ]
Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M (August 1994). "Plasticity in the adult human oligodendrocyte lineage" . The Journal of Neuroscience . 14 (8): 4571–87. doi :10.1523/JNEUROSCI.14-08-04571.1994 . PMC 6577192 . PMID 7519254 .
Armstrong RC, Kim JG, Hudson LD (August 1995). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia . 14 (4): 303–21. doi :10.1002/glia.440140407 . PMID 8530187 . S2CID 38779689 .
Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (February 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex" . Molecular and Cellular Biology . 17 (2): 571–83. doi :10.1128/mcb.17.2.571 . PMC 231782 . PMID 9001210 .
Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD (October 1997). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system" . Journal of Neuroscience Research . 50 (2): 272–90. doi :10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A . PMID 9373037 . S2CID 37120295 .
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 5 (6): 355–64. doi :10.1093/dnares/5.6.355 . PMID 10048485 .
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 6 (3): 197–205. doi :10.1093/dnares/6.3.197 . PMID 10470851 .
Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S (January 2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Research. Developmental Brain Research . 140 (1): 85–92. doi :10.1016/S0165-3806(02)00585-0 . PMID 12524179 .
Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (January 2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Molecular and Cellular Neurosciences . 25 (1): 111–23. doi :10.1016/j.mcn.2003.10.001 . PMID 14962745 . S2CID 28151272 .
Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (May 2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS" . Glia . 55 (7): 687–97. doi :10.1002/glia.20492 . PMC 2789289 . PMID 17330875 .
External links [ edit ]
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors