Protein-coding gene in the species Homo sapiens
Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor . IL10RA is its human gene .
IL10RA has also been designated CDw210a (cluster of differentiation w210a).
The protein encoded by this gene is a receptor for interleukin 10 . This protein is structurally related to interferon receptors . It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines . This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2 /PI 3-kinase /AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases .[5]
Interleukin 10 receptor, alpha subunit has been shown to interact with:
^ a b c GRCh38: Ensembl release 89: ENSG00000110324 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032089 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: IL10RA interleukin 10 receptor, alpha" .
^ Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993). "A receptor for interleukin 10 is related to interferon receptors" . Proc. Natl. Acad. Sci. U.S.A . 90 (23): 11267–71. Bibcode :1993PNAS...9011267H . doi :10.1073/pnas.90.23.11267 . PMC 47963 . PMID 8248239 .
^ Josephson K, Logsdon NJ, Walter MR (July 2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site" . Immunity . 15 (1): 35–46. doi :10.1016/s1074-7613(01)00169-8 . PMID 11485736 .
^ Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula SK, Zavodny PJ, Chou CC (May 1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor" . J. Biol. Chem . 270 (21): 12906–11. doi :10.1074/jbc.270.21.12906 . PMID 7759550 .
^ Josephson K, McPherson DT, Walter MR (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D . 57 (Pt 12): 1908–11. doi :10.1107/s0907444901016249 . PMID 11717514 .
^ Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (May 1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization" . Eur. J. Biochem . 262 (1): 134–41. doi :10.1046/j.1432-1327.1999.00363.x . PMID 10231374 .
^ Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (December 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation" . J. Biol. Chem . 277 (50): 48220–6. doi :10.1074/jbc.M205757200 . PMID 12374810 .
^ Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors" . J. Immunol . 169 (3): 1302–8. doi :10.4049/jimmunol.169.3.1302 . PMID 12133952 .
Donnelly RP, Dickensheets H, Finbloom DS (1999). "The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes" . J. Interferon Cytokine Res . 19 (6): 563–73. doi :10.1089/107999099313695 . PMID 10433356 . S2CID 35958614 .
Carson WE, Lindemann MJ, Baiocchi R, Linett M, Tan JC, Chou CC, Narula S, Caligiuri MA (1995). "The functional characterization of interleukin-10 receptor expression on human natural killer cells" . Blood . 85 (12): 3577–85. doi :10.1182/blood.V85.12.3577.bloodjournal85123577 . PMID 7540068 .
Ho AS, Wei SH, Mui AL, Miyajima A, Moore KW (1995). "Functional regions of the mouse interleukin-10 receptor cytoplasmic domain" . Mol. Cell. Biol . 15 (9): 5043–53. doi :10.1128/mcb.15.9.5043 . PMC 230751 . PMID 7544437 .
Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula SK, Zavodny PJ, Chou CC (1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor" . J. Biol. Chem . 270 (21): 12906–11. doi :10.1074/jbc.270.21.12906 . PMID 7759550 .
Taniyama T, Takai S, Miyazaki E, Fukumura R, Sato J, Kobayashi Y, Hirakawa T, Moore KW, Yamada K (1995). "The human interleukin-10 receptor gene maps to chromosome 11q23.3". Hum. Genet . 95 (1): 99–101. doi :10.1007/BF00225083 . PMID 7814035 . S2CID 205672 .
Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor" . J. Immunol . 152 (4): 1821–9. doi :10.4049/jimmunol.152.4.1821 . PMID 8120391 .
Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors" . Proc. Natl. Acad. Sci. U.S.A . 90 (23): 11267–71. Bibcode :1993PNAS...9011267H . doi :10.1073/pnas.90.23.11267 . PMC 47963 . PMID 8248239 .
Tan JC, Indelicato SR, Narula SK, Zavodny PJ, Chou CC (1993). "Characterization of interleukin-10 receptors on human and mouse cells" . J. Biol. Chem . 268 (28): 21053–9. doi :10.1016/S0021-9258(19)36892-9 . PMID 8407942 .
Lai CF, Ripperger J, Morella KK, Jurlander J, Hawley TS, Carson WE, Kordula T, Caligiuri MA, Hawley RG, Fey GH, Baumann H (1996). "Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements" . J. Biol. Chem . 271 (24): 13968–75. doi :10.1074/jbc.271.24.13968 . PMID 8662928 .
Zdanov A, Schalk-Hihi C, Wlodawer A (1997). "Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor" . Protein Sci . 5 (10): 1955–62. doi :10.1002/pro.5560051001 . PMC 2143256 . PMID 8897595 .
Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex" . EMBO J . 16 (19): 5894–903. doi :10.1093/emboj/16.19.5894 . PMC 1170220 . PMID 9312047 .
Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization" . Eur. J. Biochem . 262 (1): 134–41. doi :10.1046/j.1432-1327.1999.00363.x . PMID 10231374 .
Müschen A, Mirmohammadsadegh A, Jarzebska-Deussen B, Abts HF, Ruzicka T, Michel G (1999). "Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes". Inflamm. Res . 48 (10): 539–43. doi :10.1007/s000110050500 . PMID 10563471 . S2CID 22779271 .
Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G (2001). "Regulatory activity of autocrine IL-10 on dendritic cell functions" . J. Immunol . 166 (7): 4312–8. doi :10.4049/jimmunol.166.7.4312 . PMID 11254683 .
Josephson K, Logsdon NJ, Walter MR (2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site" . Immunity . 15 (1): 35–46. doi :10.1016/S1074-7613(01)00169-8 . PMID 11485736 .
Crepaldi L, Gasperini S, Lapinet JA, Calzetti F, Pinardi C, Liu Y, Zurawski S, de Waal Malefyt R, Moore KW, Cassatella MA (2001). "Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10" . J. Immunol . 167 (4): 2312–22. doi :10.4049/jimmunol.167.4.2312 . PMID 11490020 .
Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW (2001). "IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase" . J. Immunol . 167 (8): 4436–42. doi :10.4049/jimmunol.167.8.4436 . PMID 11591769 .
Josephson K, McPherson DT, Walter MR (2002). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D . 57 (Pt 12): 1908–11. doi :10.1107/S0907444901016249 . PMID 11717514 .
Wolk K, Kunz S, Asadullah K, Sabat R (2002). "Cutting edge: immune cells as sources and targets of the IL-10 family members?" . J. Immunol . 168 (11): 5397–402. doi :10.4049/jimmunol.168.11.5397 . PMID 12023331 .
PDB gallery
1j7v : HUMAN IL-10 / IL-10R1 COMPLEX
1lqs : CRYSTAL STRUCTURE OF HUMAN CYTOMEGALOVIRUS IL-10 BOUND TO SOLUBLE HUMAN IL-10R1
1y6k : Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain
1y6m : Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain
1y6n : Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .