Brain Drain may refer to:

• Brain drain, an emigration term
• Brain Drain (album), a Ramones album
• Brain Drain (comics), a Marvel Comics character
• "Brain Drain" (Charmed), an episode of the television series Charmed
• Brain Drain (film), 2009 Spanish comedy film directed by Fernando González Molina
• "Brain Drain", an episode of the Disney cartoon series Phineas and Ferb
• "Brain Drain", an episode of the Nickelodeon cartoon series Fanboy & Chum Chum
• Brain Drain, the slide filled with soap in Nickelodeon's game show, BrainSurge
• The Brain Drain, a BBC comedy panel show
• Brain Drain also called human capital flight is emigration of skilled people to other countries.