Gene duplication provides raw material for functional innovation. Recent advances have
shed light on two fundamental questions regarding gene duplication: which genes tend to …

In this essay, we revisit the status of yeast as a model system for biology. We first summarize
important contributions of yeast to eukaryotic biology that we anticipated in 1988 in our first …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Transcription factors (TFs) that bind common DNA motifs in vitro occupy distinct sets of
promoters in vivo, raising the question of how binding specificity is achieved. TFs are …

To tackle incongruence, the topological conflict between different gene trees, phylogenomic
studies couple concatenation with practices such as rogue taxon removal or the use of …

INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

Nearly all mitochondrial proteins are nuclear-encoded and are targeted to their
mitochondrial destination from the cytosol. Here, we used proximity-specific ribosome …

RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is
conserved in diverse eukaryotic species but has been lost in the model budding yeast …

Whole-genome duplications have shaped the genomes of several vertebrate, plant, and
fungal lineages. Earlier studies have focused on establishing when these events occurred …

Genes for which homologs can be detected only in a limited group of evolutionarily related
species, called “lineage-specific genes,” are pervasive: Essentially every lineage has them …