Objective

While congenital Zika infection may lead to significant fetal neurologic abnormalities, little is known about the postnatal consequences of Zika exposure to apparently asymptomatic fetuses. Our aim was to examine the postnatal outcomes of infants exposed to maternal Zika infection during pregnancy.

Study Design

This is an ongoing prospective, observational cohort study from a large-scale, county hospital-based prenatal Zika screening program in a southern border state. All women reporting travel to an at-risk region during pregnancy were screened with serum Zika IgM or PCR as appropriate. Infants born to women with laboratory evidence of Zika infection during pregnancy underwent laboratory and comprehensive neurologic evaluation at birth, and were surveyed for developmental milestones and head circumference (HC) measurements at local pediatric clinics. HC measurements were compared …