Cannabis Ruderalis

Authors
Inga Holmdahl, Samantha Bents, Rachel E Baker, Jean-Sebastien Casalegno, Nídia Sequeira Trovão, Sang Woo Park, Jessica E Metcalf, Cécile Viboud, Bryan Grenfell
Publication date
2023/12/29
Description
Nonpharmaceutical interventions (NPIs) implemented during the COVID-19 pandemic have disrupted the dynamics of respiratory syncytial virus (RSV) on a global scale; however, the cycling of RSV subtypes in the pre-and post-pandemic period remains poorly understood. Here, we use a two subtype RSV model supplemented with epidemiological data to study the impact of NPIs on the two circulating subtypes, RSV-A and RSV-B. The model is calibrated to historic RSV subtype data from the United Kingdom and Finland and predicts a tendency for RSV-A dominance prior to RSV-B following the implementation of NPIs. Using a global genetic dataset, we confirm that RSV-A has prevailed over RSV-B in the post-pandemic period, consistent with a higher R 0 for RSV-A. With new RSV infant monoclonals and maternal and elderly vaccines becoming widely available, these results may have important implications for understanding intervention effectiveness in the context of disrupted subtype dynamics.

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