CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome PK Todd, SY Oh, A Krans, F He, C Sellier, M Frazer, AJ Renoux, K Chen, ... Neuron 78 (3), 440-455, 2013 | 509 | 2013 |
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection NB Nedelsky, PK Todd, JP Taylor Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1782 (12 …, 2008 | 416 | 2008 |
Discovery of a biomarker and lead small molecules to target r (GGGGCC)-associated defects in c9FTD/ALS Z Su, Y Zhang, TF Gendron, PO Bauer, J Chew, WY Yang, E Fostvedt, ... Neuron 83 (5), 1043-1050, 2014 | 381 | 2014 |
The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95 PK Todd, KJ Mack, JS Malter Proceedings of the National Academy of Sciences 100 (24), 14374-14378, 2003 | 361 | 2003 |
RNA‐mediated neurodegeneration in repeat expansion disorders PK Todd, HL Paulson Annals of neurology 67 (3), 291-300, 2010 | 295 | 2010 |
Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome C Sellier, F Freyermuth, R Tabet, T Tran, F He, F Ruffenach, V Alunni, ... Cell reports 3 (3), 869-880, 2013 | 255 | 2013 |
RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response KM Green, MR Glineburg, MG Kearse, BN Flores, AE Linsalata, SJ Fedak, ... Nature communications 8 (1), 2005, 2017 | 224 | 2017 |
Translation of expanded CGG repeats into FMRpolyG is pathogenic and may contribute to fragile X tremor ataxia syndrome C Sellier, RAM Buijsen, F He, S Natla, L Jung, P Tropel, A Gaucherot, ... Neuron 93 (2), 331-347, 2017 | 218 | 2017 |
Molecular mechanisms underlying nucleotide repeat expansion disorders I Malik, CP Kelley, ET Wang, PK Todd Nature reviews Molecular cell biology 22 (9), 589-607, 2021 | 209 | 2021 |
CGG repeat-associated non-AUG translation utilizes a cap-dependent scanning mechanism of initiation to produce toxic proteins MG Kearse, KM Green, A Krans, CM Rodriguez, AE Linsalata, ... Molecular cell 62 (2), 314-322, 2016 | 166 | 2016 |
Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance HN Bell, RJ Rebernick, J Goyert, R Singhal, M Kuljanin, SA Kerk, ... Cancer cell 40 (2), 185-200. e6, 2022 | 128 | 2022 |
RAN translation—What makes it run? KM Green, AE Linsalata, PK Todd Brain research 1647, 30-42, 2016 | 112 | 2016 |
histone deacetylases suppress CGG repeat–induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome PK Todd, SY Oh, A Krans, UB Pandey, NA Di Prospero, KT Min, JP Taylor, ... PLoS genetics 6 (12), e1001240, 2010 | 108 | 2010 |
RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome SY Oh, F He, A Krans, M Frazer, JP Taylor, HL Paulson, PK Todd Human molecular genetics 24 (15), 4317-4326, 2015 | 103 | 2015 |
Neurodegeneration the RNA way AJ Renoux, PK Todd Progress in neurobiology 97 (2), 173-189, 2012 | 99 | 2012 |
Behavioral sensitization and extracellular dopamine responses to amphetamine after various treatments R Kuczenski, DS Segal, PK Todd Psychopharmacology 134, 221-229, 1997 | 86 | 1997 |
Repeat-associated non-AUG (RAN) translation and other molecular mechanisms in Fragile X Tremor Ataxia Syndrome MR Glineburg, PK Todd, N Charlet-Berguerand, C Sellier Brain research 1693, 43-54, 2018 | 82 | 2018 |
New pathologic mechanisms in nucleotide repeat expansion disorders CM Rodriguez, PK Todd Neurobiology of disease 130, 104515, 2019 | 80 | 2019 |
Sensory stimulation increases cortical expression of the fragile X mental retardation protein in vivo PK Todd, KJ Mack Molecular brain research 80 (1), 17-25, 2000 | 79 | 2000 |
Repeat‐associated non‐AUG translation from antisense CCG repeats in fragile X tremor/ataxia syndrome A Krans, MG Kearse, PK Todd Annals of neurology 80 (6), 871-881, 2016 | 74 | 2016 |