Protein-coding gene in the species Homo sapiens
Mitochondrial import receptor subunit TOM22 homolog (hTom22) is a protein that in humans is encoded by the TOMM22 gene .[5] [6] [7]
The protein encoded by this gene is an integral membrane protein of the outer mitochondrial membrane . The encoded protein interacts with TOMM20 and TOMM40, and with other proteins forms a complex – the translocase of the outer membrane , to import cytosolic preproteins into the mitochondrion.[7]
See also [ edit ]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000100216 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022427 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Yano M, Hoogenraad N, Terada K, Mori M (Oct 2000). "Identification and functional analysis of human Tom22 for protein import into mitochondria" . Mol Cell Biol . 20 (19): 7205–13. doi :10.1128/MCB.20.19.7205-7213.2000 . PMC 86274 . PMID 10982837 .
^ Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K (Nov 2000). "Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane" . J Biol Chem . 275 (41): 31996–2002. doi :10.1074/jbc.M004794200 . PMID 10900208 .
^ a b "Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)" .
Further reading [ edit ]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Suzuki H, Okazawa Y, Komiya T, et al. (2001). "Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane" . J. Biol. Chem . 275 (48): 37930–6. doi :10.1074/jbc.M006558200 . PMID 10980201 .
Johnston AJ, Hoogenraad J, Dougan DA, et al. (2003). "Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane" . J. Biol. Chem . 277 (44): 42197–204. doi :10.1074/jbc.M205613200 . PMID 12198123 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Yano M, Terada K, Mori M (2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins" . J. Cell Biol . 163 (1): 45–56. doi :10.1083/jcb.200305051 . PMC 2173431 . PMID 14557246 .
Yano M, Terada K, Mori M (2004). "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity" . J. Biol. Chem . 279 (11): 10808–13. doi :10.1074/jbc.M311710200 . PMID 14699115 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 . PMC 545604 . PMID 15461802 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40" . J. Biol. Chem . 280 (12): 11535–43. doi :10.1074/jbc.M413816200 . PMID 15644312 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 . PMID 17081983 .
Bellot G, Cartron PF, Er E, et al. (2007). "TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax" . Cell Death Differ . 14 (4): 785–94. doi :10.1038/sj.cdd.4402055 . PMID 17096026 .