St. Leo Church or St. Leo's Catholic Church or variations may refer to:

• St. Leo's Roman Catholic Church, Mimico, in Toronto, Ontario, Canada
• Chapel of St Leo, Żurrieq, Malta

• Saint Leo the Great Parish, San Jose, California
• St. Leo's Church (Baltimore, Maryland), listed on the National Register of Historic Places (NRHP)
• St. Leo's Catholic Church (Lewistown, Montana), NRHP-listed
• St. Leo Church (New York City)

• St. Leonard's Church (disambiguation)