Cannabis Ruderalis

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Revision as of 05:33, 6 May 2008

JWH-176
Legal status
Legal status
  • In general: legal
Identifiers
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H24
Molar mass324.457 g/mol g·mol−1
3D model (JSmol)
  • CCCCCc(c3)c1ccccc1c3=Cc2cccc4ccccc24

JWH-171 is an analgesic drug which acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is only 51nM, making it slightly less potent than THC itself,[1] however JWH-171 is particularly notable in that it is a hydrocarbon containing no heteroatoms. This demonstrates that reasonably high-affinity cannabinoid binding and agonist effects can be produced by compounds with no hydrogen bonding capacity at all, relying merely on Van der Waals interactions to bind to the receptor.[2]

References

  1. ^ Huffman JW, Padgett LW. Recent Developments in the Medicinal Chemistry of Cannabimimetic Indoles, Pyrroles and Indenes. Current Medicinal Chemistry, 2005; 12: 1395-1411.
  2. ^ Roger Pertwee. Cannabinoids. Handbook of Experimental Pharmacology Volume 168, p 269. Springer. ISBN 3-540-22565-X


source: https://en.wikipedia.org/wiki/Special%3ADiff%2F210507471

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