Madonna is a contraction of an Italian phrase meaning "My Lady".

Madonna may refer to:

• Mary (mother of Jesus), from which all other uses ultimately derive
  • Madonna (art), a portrait of Mary
  • Madonna and Child, portraits of Mary and the infant Christ
• Madonna (entertainer), an American singer and actress
  • Madonna (Madonna album)
• Madonna (Trail of Dead album)
• Madonna (Edvard Munch), a painting by Edvard Munch
• Madonna (skateboarding trick)

Madonna may also be used for:

• Madonna University, a college in Livonia, Michigan
• Madonna Inn, a resort hotel in California
• Madonna del Ghisallo, a hill close to Lake Como in Italy
• Madonna of the Trail, a series of historical monuments from Maryland to California
• Madonna Oriente, a moon goddess
• Black Madonna, a statue or painting of Mary in which she is depicted with black skin
• House of the Black Madonna, a cubist building in Prague, Czech Republic
• Madonna lily, a plant in the genus Lilium
• Madonna piercing, a type of facial piercing that can resemble a mole
• "Lady Madonna", a song by The Beatles
• "Black Madonna", a song by Noe Venable
• Madonna, the top F1 team in the video games Super Monaco GP and Ayrton Senna's Super Monaco GP II

People with the given name Madonna

• Madonna Louise Ciccone, American singer and actress, who is known professionally as "Madonna".
• Madonna Wayne Gacy, stage name of Stephen Gregory Bier Jr, keyboard player for Marilyn Manson