SKL can stand for:
- Finnish Christian League (Suomen Kristillinen Liitto)
- Seekriegsleitung (Naval Warfare Command), Germany, WWI
- AN/PYQ-10 Simple Key Loader
- 1. SKL, Premier A Slovenian Basketball League
- 2. SKL, Slovenian Second Basketball League
- Serine-lysine-leucine, a peroxisome targeting signal 1 in protein targeting
- Singaperumal Koil railway station, Tamil Nadu, India (station code)
- Skylake, a CPU microarchitecture from Intel
- Super Kabaddi League, Pakistan
- Intel Skylake CPU microarchitecture product suffix
- Sumerian King List