Pignatelli (Italian pronunciation: [piɲɲaˈtɛlli]) is an Italian surname which may refer to:

People[edit]

• House of Pignatelli, an aristocratic family of Naples
• Fabio Pignatelli (born 1953), an Italian musician
• Luca Pignatelli (born 1962), an Italian artist
• William Pignatelli (born 1959), an American state politician from Massachusetts

Places[edit]

• Villa Pignatelli, a museum in Naples
• Santa Maria Assunta dei Pignatelli, a church in Naples