Protein-coding gene in the species Homo sapiens
Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene .[5] [6] [7]
Clinical significance [ edit ]
The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease .[8]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000221823 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033953 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively" . Cytogenet Cell Genet . 72 (2–3): 236–41. doi :10.1159/000134198 . PMID 8978785 .
^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA . 8 (9): 675–82. doi :10.1089/dna.1.1989.8.675 . PMID 2558868 .
^ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" .
^ Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ (ed.). "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease" . PLOS Genet . 6 (9): e1001101. doi :10.1371/journal.pgen.1001101 . PMC 2940763 . PMID 20862329 .
Further reading [ edit ]
Kawamura A, Su MS (1995). "Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain" . J. Biol. Chem . 270 (26): 15463–6. doi :10.1074/jbc.270.26.15463 . PMID 7541044 .
Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature . 378 (6557): 641–4. Bibcode :1995Natur.378..641K . doi :10.1038/378641a0 . PMID 8524402 . S2CID 4337105 .
Feng B, Stemmer PM (1999). "Interactions of calcineurin A, calcineurin B, and Ca2+". Biochemistry . 38 (38): 12481–9. doi :10.1021/bi990492w . PMID 10493818 .
Stratakis CA, Taymans SE (1999). "Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15)" . DNA Seq . 9 (4): 227–30. doi :10.3109/10425179809105209 . PMID 10520753 .
Nishio H, Matsui K, Tsuji H, et al. (2000). "Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis". Histochem. Cell Biol . 114 (1): 9–14. doi :10.1007/s004180000168 . PMID 10959817 . S2CID 21530150 .
Sokal I, Li N, Verlinde CL, et al. (2001). "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1)" . Biochim. Biophys. Acta . 1498 (2–3): 233–51. doi :10.1016/S0167-4889(00)00099-9 . PMID 11108966 .
Graef IA, Chen F, Chen L, et al. (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature" . Cell . 105 (7): 863–75. doi :10.1016/S0092-8674(01)00396-8 . PMID 11439183 . S2CID 5278706 .
Al-Daraji WI, Grant KR, Ryan K, et al. (2002). "Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A." J. Invest. Dermatol . 118 (5): 779–88. doi :10.1046/j.1523-1747.2002.01709.x . PMID 11982754 .
Huai Q, Kim HY, Liu Y, et al. (2002). "Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes" . Proc. Natl. Acad. Sci. U.S.A . 99 (19): 12037–42. Bibcode :2002PNAS...9912037H . doi :10.1073/pnas.192206699 . PMC 129394 . PMID 12218175 .
Jin L, Harrison SC (2002). "Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin" . Proc. Natl. Acad. Sci. U.S.A . 99 (21): 13522–6. Bibcode :2002PNAS...9913522J . doi :10.1073/pnas.212504399 . PMC 129706 . PMID 12357034 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha" . Virology . 303 (1): 174–80. doi :10.1006/viro.2002.1676 . PMID 12482669 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Bittinger MA, McWhinnie E, Meltzer J, et al. (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins" . Curr. Biol . 14 (23): 2156–61. doi :10.1016/j.cub.2004.11.002 . PMID 15589160 . S2CID 5934014 .
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4" . Nature . 434 (7034): 724–31. Bibcode :2005Natur.434..724H . doi :10.1038/nature03466 . PMID 15815621 .
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Winslow MM, Gallo EM, Neilson JR, Crabtree GR (2006). "The calcineurin phosphatase complex modulates immunogenic B cell responses" . Immunity . 24 (2): 141–52. doi :10.1016/j.immuni.2005.12.013 . PMID 16473827 .
Liu Q, Wilkins BJ, Lee YJ, et al. (2006). "Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth" . Mol. Cell. Biol . 26 (10): 3785–97. doi :10.1128/MCB.26.10.3785-3797.2006 . PMC 1489013 . PMID 16648474 .
PDB gallery
1aui : HUMAN CALCINEURIN HETERODIMER
1m63 : Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
1mf8 : Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
1tco : TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
2p6b : Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide