Protein-coding gene in the species Homo sapiens
cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.[4][5]
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000186642 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
- ^ "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".
Further reading[edit]
- Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, Van Laak V (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. 37 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892. S2CID 1060183.
- Seybold J, Thomas D, Witzenrath M, Boral S, Hocke AC, Bürger A, Hatzelmann A, Tenor H, Schudt C (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061.
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Martinez SE, Wu AY, Glavas NA, Tang XB, Turley S, Hol WG, Beavo JA (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. Bibcode:2002PNAS...9913260M. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124.
- Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. doi:10.1055/s-0037-1613099. PMID 12038792. S2CID 4637804.
- Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964. S2CID 26315564.
- Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.
PDB gallery |
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1mc0: Regulatory Segment of Mouse 3',5'-Cyclic Nucleotide Phosphodiesterase 2A, Containing the GAF A and GAF B Domains
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1z1l: The Crystal Structure of the Phosphodiesterase 2A Catalytic Domain
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