Oxus may refer to :
- Oxus River, also called the Amu Darya, Amu or Amo River, a major river in Central Asia.
- Oxus valley (disambiguation)
- Oxus civilization, a bronze age civilization of central Asia
- Oxus (god), an Eastern Iranian god regarded as the personification of the Amu Darya
- Oxus Cobra, also known as the Caspian cobra, Central Asian cobra, or Russian cobra