Nikos, Nikolaos or Nikolas Papadopoulos may refer to:
- Niccolò Comneno Papadopoli (1655–1740), Cretan-Italian lawyer and historian
- Nikolaos Papadopoulos (1769-1820), scholar and trader from Epirus
- Nikolaos Papadopoulos (fighter), fighter in the Greek War of Independence
- Niccolò Papadopoli a.k.a. Nicolo Papadopoli Aldobrandini (1841-1922), Italian politician from Venice
- Nikolaos Papadopoulos (scholar) (1933-2012), Greek Old Testament scholar
- Nikos Papadopoulos (Swedish politician) (b. 1939)
- Nikos Papadopoulos (general) (d. 1971), Greek general
- Nikos Papadopoulos (actor) (b. 1962)
- Nick Papadopolos (b. 1966), British priest
- Nikos Papadopoulos (footballer, born 1971)
- Nikolas Papadopoulos (b. 1973), Cypriot lawyer and politician
- Nikos Papadopoulos (Greek footballer, born 1990), goalkeeper
- Nikos Papadopoulos (Greek politician), MP elected for SYRIZA in September 2015
- Nick Papadopoulos (Australian footballer), played for Western Suburbs SC