Michael Griffin may refer to:

Sports[edit]

• Michael Griffin II (born 1998), American gridiron football player
• Michael Griffin (American football) (born 1985), football player
• Michael Griffin (footballer) (1887–?), English footballer
• Mike Griffin (outfielder) (1865–1908), American baseball center fielder
• Mike Griffin (pitcher) (born 1957), American baseball pitcher
• Mike Griffin (basketball), American college basketball coach

Others[edit]

• Michael D. Griffin (born 1949), former NASA administrator 2005–09 and Under Secretary of Defense for Research and Engineering
• Michael F. Griffin (born 1962), American murdererer of David Gunn
• Michael Griffin (Irish priest) (1892–1920), Irish Roman Catholic priest shot dead during the Anglo-Irish War
• Michael Griffin (Wisconsin politician) (1842–1899), American politician
• Michael Griffin (Indiana politician) (active from 2022), American politician from Indiana
• Michael Griffin (escape artist) (born 1961), American escape artist, magician and illusionist
• Michael Griffin (surgeon), British surgeon and clinical researcher