Guillermo Garcia may refer to:
- Guillermo García (actor) (born 1981), Venezuelan actor
- Guillermo García (swimmer) (born 1955), Mexican Olympic swimmer
- Guillermo García Oropeza (born 1937), Mexican writer
- Guillermo García-López (born 1983), Spanish professional tennis player
- Guillermo Garcia (baseball) (born 1972), former Major League Baseball catcher
- Guillermo García (sailor) (born 1944), Mexican Olympic sailor
- Guillermo Garcia (volleyball) (born 1983), Argentina national volleyballer
- Guillermo Garcia (tennis), Chilean tennis player at the 1955 & 1956 US Open
- Guillermo García Cantú (born 1960), Mexican actor
- Guillermo Garcia Gonzales (1953–1990), Cuban chess grandmaster
- Guillermo García (Salvadoran footballer) (born 1969), Salvadoran football player
- Guillermo García, model from Zaragoza; Mister Spain 2009
- Guillermo García (musician) (born 1988), Mexican guitarist for S7N