GWB may refer to:
- Baylor University Golden Wave Band
- DeKalb County Airport (Indiana)
- The Geochemist's Workbench, a scientific modelling suite
- George Warren Brown School of Social Work of Washington University in St. Louis
- George Washington Bridge, linking Washington Heights, Manhattan to Fort Lee, New Jersey, United States
- George W. Bush (born 1946), 43rd president of the United States
- Gravitational wave background -- stochastic background of gravitational waves permeating the Universe
- Great Western Bank (1907–present), an American bank
- gwb ISO 639-3 code for the Gwa language
- Gypsum wall board, a.k.a. drywall, a construction material