GLC may refer to:

Music[edit]

• GLC (rapper) (born 1975), American rapper signed to Kanye West's G.O.O.D. Music record label
• Goldie Lookin Chain, Welsh rappers

Technology[edit]

• Gas-liquid chromatography
• Geographic Locator Codes
• Global Linear Collider, now merged into the International Linear Collider proposal
• Great Lakes Central Railroad
• Mazda GLC, a compact car
• Mercedes-Benz GLC, an SUV

Television[edit]

• "GLC: The Carnage Continues...", an episode of the television series The Comic Strip Presents...
• God's Learning Channel, an American television station

Other uses[edit]

• Glasgow Central station, in Scotland
• Glucose
• Government-linked company or corporation
• Government Law Center, a research institute at Albany Law School, Albany, New York, United States
• Government Law College (disambiguation)
• Greater London Council
• Great Lakes Commission
• Green Lake Crew, a rowing club based in Seattle, Washington, United States
• Gutnius Lutheran Church, in Papua New Guinea