DR2 may refer to:
- Dead Rising 2, a 2010 video game
- Danganronpa 2: Goodbye Despair, a 2012 video game
- DR-2, a highway in the Dominican Republic
- DR2 register, a debug register of x86 processors
- DR2 (car), an Italian automobile by DR Motor Company
- Demolition Records, a UK based record label
- DR P2, a Danish radio station from DR
- DR2, a Danish television channel from DR
- Gaia Data Release 2, the second publication of astrometric data
- DR2 (DR for "Dreieckrechner"), a German flight computer manufactured as of 1936