Cannabis Ruderalis

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Cod-THC
Identifiers
  • [(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl] [(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-yl] carbonate
Chemical and physical data
FormulaC40H49NO6
Molar mass639.833 g·mol−1
3D model (JSmol)
  • CN1CC[C@@]23c4c5C[C@@H]1[C@@H]2C=C[C@H](OC(=O)Oc1cc(CCCCC)cc2OC(C)(C)[C@@H]6CCC(C)=C[C@H]6c21)[C@@H]3Oc4c(OC)cc5

Cod-THC (Codeine Δ9-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.[1][2][3]

See also[edit]

References[edit]

  1. ^ Banerjee A, Hayward JJ, Trant JF (May 2023). ""Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential". Organic & Biomolecular Chemistry. 21 (18): 3715–3732. doi:10.1039/d3ob00068k. PMID 36825573. S2CID 256792029.
  2. ^ US 2008/0176885, Holtman JR, Crooks PA, Dhooper HK, "Novel synergistic opioid-cannabinoid codrug for pain management.", published 24 July 2008, assigned to University of Kentucky and Insys Therapeutics Inc. 
  3. ^ Crooks PA, Dhooper HK, Chakraborty U (2011). "Improving the Use of Drug Combination through the Codrug Approach". In Rautio J (ed.). Prodrugs and Targeted Delivery: Towards Better ADME Properties. Wiley. pp. 345–383 (374–376). ISBN 978-3-527-63318-0.
source: https://en.wikipedia.org/wiki/Cod-THC

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