Centre of excellence or center of excellence may refer to:

• Australian Research Council (ARC) Centres of Excellence, Australian and international research collaborations
• Center of excellence, a team, shared facility or an organizational entity that concentrates on a focus area
• Centre of Excellence on Public Security (CEPS), a think tank based in Rio de Janeiro, Brazil
• Cenex, the UK Centre of Excellence for Low Carbon and fuel cell technologies
• CERT Group of Companies, the Centre of Excellence for Applied Research and Training
• Commonwealth Bank Centre of Excellence, the name for the Australian Cricket Academy
• CECT, the Central Institute of Classical Tamil, established by the government of India with a view to promoting the cause of Classical Tamil
• Centre of Excellence for Biosecurity Risk Analysis (CEBRA), Melbourne, Australia
• EU CBRN Risk Mitigation CoE Initiative, the EU Centres of Excellence on Chemical, Biological, Radiological and Nuclear Risk Mitigation (CBRN CoE)
• NATO Centres of Excellence, an initiative of NATO to request the NATO nations to set up think tank, knowledge development centres