Casey Jones (1863–1900) was an American railroad engineer.

Casey Jones may also refer to:

• Casey Jones (ice hockey) (born 1968), Canadian ice hockey coach
• Casey Jones (politician) (1915–2002), former member of the Ohio House of Representatives; also a professional basketball player in the NBL during the 1940s
• Casey Jones (catcher) (1918–1998), American Negro league baseball player
• Casey Jones (outfielder), American Negro league baseball player
• Casey Jones (musician) (1939–2017), solo blues artist and former drummer for guitarist Albert Collins
• Casey Veggies (born 1993), hip hop artist
• Casey Jones, former member of Blessed by a Broken Heart
• Casey Jones (1936–2022), stage name of British singer Brian Cassar
• Casey Jones, alternate identity for radio personality Al Anthony
• Casey Jones, television persona of Lunch With Casey show host Roger Awsumb
• Casey Jones, author of the American comic book All Fall Down

• "The Ballad of Casey Jones", a c. 1909 folk song about the railroad engineer
• "Casey Jones" (Grateful Dead song), a 1970 song by the Grateful Dead, also about the railroad engineer
• Casey Jones (band), a straight edge hardcore punk band from Florida

• Casey Jones (play), a 1938 play by Robert Ardrey
• Casey Jones (TV series), a 1957 television show starring Alan Hale Jr
• Casey Jones (Teenage Mutant Ninja Turtles), a character from the Teenage Mutant Ninja Turtles series
  • Casey Jones (film), a 2011 fan film based on the Teenage Mutant Ninja Turtles character

• K. C. Jones (1932–2020), American basketball player and coach
• K. C. Jones (American football) (born 1974), American football center