![](https://upload.wikimedia.org/wikipedia/commons/thumb/2/24/Bradsher_Cycloaddition_HR.png/220px-Bradsher_Cycloaddition_HR.png)
The Bradsher cycloaddition reaction, also known as the Bradsher cyclization reaction is a form of the Diels–Alder reaction which involves the [4+2] addition of a common dienophile with a cationic aromatic azadiene such as acridizinium or isoquinolinium.
The Bradsher cycloaddition was first reported by C. K. Bradsher and T. W. G. Solomons in 1958.[1][2][3]
References
[edit]- ^ C. K. Bradsher, T. W. G. Solomons (1958). "Acridizinium Ion Chemistry. II.1The Diels-Alder Reaction". J. Am. Chem. Soc. 80 (4): 933. doi:10.1021/ja01537a045.
- ^ Merck Index, 14th Ed.
- ^ C. K. Bradsher, J. A. Stone (1968). "Nature of the addition of dienophiles to the acridizinium ion". Journal of Organic Chemistry. 33 (2): 519. doi:10.1021/jo01266a009.