BSE may refer to:

• Bovine spongiform encephalopathy, also known as mad cow disease, a neurodegenerative disease of cattle
• Breast self-examination

• Bahrain Stock Exchange, Bahrain
• Baku Stock Exchange, Azerbaijan
• Barbados Stock Exchange
• Beijing Stock Exchange, China
• Bombay Stock Exchange, Mumbai, India
• Boston Stock Exchange, Massachusetts, US
• Botswana Stock Exchange in Gaborone, Botswana
• Budapest Stock Exchange, Hungary
• Bulgarian Stock Exchange – Sofia, BSE-Sofia

• Blueprint for a Safer Economy, California classification of safe practices within a lockdown economy
• Britain Stronger in Europe, a lobbying group
• Board of Secondary Education, Odisha, India
• Biological systems engineering
• Bury St Edmunds railway station (station code), Suffolk, England
• Backscattered electron (see scanning electron microscope)
• Blender Stack Exchange, a Q&A site for the Blender 3D software
• BSE (satellite), a Japanese satellite
• Bachelor of Science in Engineering, an undergraduate academic degree awarded to a student after 3-5 years of studying engineering at a university or college
• Black Sun Empire, a Dutch drum and bass group
• Bethe–Salpeter equation, an equation in quantum field theory
• Bendigo South East College, a secondary school in Victoria, Australia
• Banco de Seguros del Estado, a Uruguayan state-owned insurance company
• Sematan Airport (IATA code: BSE), an airport in Sarawak, Malaysia

• Creutzfeldt–Jakob disease, sometimes called a human form of bovine spongiform encephalopathy