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Could someone who understands DSM-IV classification and terminology check the rates of MDMA "abuse" and "dependence" (I'm not sure what is the difference between these terms). This MDMA article currently states "One study found approximately 15% of chronic MDMA users met the DSM-IV diagnostic criteria for substance dependence." This citation is based on this PMID 19893331 study, which claims within the abstract "One fifth of the participants were screened as potentially dependent." 1/5 is 20%, not 15%. Also, why does this PMC 2891907 study claim within table 1 that, according to DSM-IV classification, MDMA has "abuse" rates between 4.4-11.2% and "dependence" rates between 44.6-66.4% (way higher that "15%"). Latter is extremely high and DSM-IV clearly defines the word "dependence" in some other way than a psychology layman like me.

Additionally, substance addiction/dependence/use disorder/abuse (whatever is the difference between these terms, I dunno?) is a complex issue, it might be better to have aggregated rates for these % estimates from multiple studies so that the rates would be more valid internationally speaking instead of citing the results of a single study. 5-HT2AR (talk) 12:06, 12 December 2020 (UTC)[reply]

In the article, the combination of MDMA with LSD, psilocybin mushrooms or ketamine are all given the name "candy-flip". However, from experience on forums and such I have gathered that MDMA + LSD = Candy Flip, MDMA + psilocybin = Hippy Flip and MDMA + ketamine = Kitty Flip. Unfortunately I do not have concrete sources, since this is something I have encountered so often that listing all instances would be impossible, however the main forum I have encountered these names at is Reddit.com

The phrase "commonly known as ecstasy (E) or molly" is misleading, given the reported increasing adulteration of illegally marketed drugs termed "ecstasy", which are likely to be "enhanced" with ketamine, caffeine, BZP, and other narcotics and stimulants.

I suggest a cautionary description would be better, i.e. "3,4-Methyl​enedioxy​methamphetamine (MDMA),[note 1] is a psychoactive drug primarily used for recreational purposes.[13] Drugs distributed as "ecstasy (E) or molly" are normally purported to contain MDMA, but are often adulterated by ketamine, caffeine, BZP, and other narcotics and stimulants." — Preceding unsigned comment added by Carusus (talk • contribs) 14:31, 10 February 2021 (UTC)[reply]

The research section currently states:

MDMA has been claimed to be useful in treating post-traumatic stress disorder, but such claims are not backed by good evidence.[181]

Source 181 actually states:

It has been suggested that MDMA, for example, possesses characteristics that make it uniquely useful for the treatment of PTSD [122]; the same has been argued for ibogaine in the treatment of SUD [42]. The high heterogeneity of the articles included in this review do not provide sufficient evidence to establish these relations

This is not the same thing. The study does not claim that the evidence of usefulness is limited, but that the evidence for unique usefulness is limited.

Moreover, a newer review that is more specific to the topic and includes more trials states the following:

The evidence for MDMA in combination with psychotherapy as a PTSD treatment was ranked "moderate"

I propose that the last sentence in the research section states:

MDMA in combination with psychotherapy has been studied as a treatment for PTSD, and four clinical trials provide moderate evidence in support of this

Juniusbrutus (talk) 04:10, 21 February 2021 (UTC)[reply]

 Done the newer review should also be cited, right? You didn't make that clear in your request, but if you think it should be cited in the article, feel free to re-open. Elliot321 (talk | contribs) 17:08, 21 February 2021 (UTC)[reply]

It is misrepresentative to state only that MDMA is primarily used for recreational purposes in the introductory sentence. Please change "primarily used for recreational purposes" to "primarily used for recreational and therapeutic purposes". It is also worth changing the end of the introduction: "MDMA is illegal in most countries and, as of 2018, has no approved medical uses." Afterwards, please add, "However, in 2017 the FDA granted breakthrough therapy designation for its use with psychotherapy for PTSD." 209.6.143.81 (talk) 21:23, 22 February 2021 (UTC)[reply]

 Not done. Please provide a reliable source showing that MDMA is actually used for therapeutic uses. Just a designation does not count. ◢  Ganbaruby!  (Say hi!) 08:17, 23 February 2021 (UTC)[reply]

MDMA was not first synthesized by Merck, it was first synthesized by Alexander “Sasha” Shulgin. 75.142.234.192 (talk) 06:25, 25 February 2021 (UTC)[reply]

 Not done: please provide reliable sources that support the change you want to be made. – robertsky (talk) 08:58, 25 February 2021 (UTC)[reply]