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Stashing this here. Has some new details about Clegg and corroborates some of the details of the Austin Chronicle article. http://www.playboy.com/articles/ecstasy-was-legal-in-1984-and-it-was-glorious

Has blurb on current usage. http://www.bbc.co.uk/newsbeat/article/36503623/danger-from-ecstasy-greater-than-ever-say-drug-experts Sizeofint (talk) 18:59, 8 November 2016 (UTC)[reply]

Additional source for history/spiritual uses to add if I can track down the original Guardian article. http://csp.org/practices/entheogens/docs/saunders-ecstasy_rel.html Sizeofint (talk) 20:29, 8 December 2016 (UTC)[reply]

Roger-Sánchez, Concepción; García-Pardo, María P.; Rodríguez-Arias, Marta; Miñarro, Jose; Aguilar, María A. (April 2016). "Neurochemical substrates of the rewarding effects of MDMA". Behavioural Pharmacology. 27: 116–132. doi:10.1097/FBP.0000000000000210. Sizeofint (talk) 08:35, 18 December 2016 (UTC)[reply]

French, Larry G. (June 1995). "The Sassafras Tree and Designer Drugs: From Herbal Tea to Ecstasy". Journal of Chemical Education. 72 (6): 484. doi:10.1021/ed072p484. Sizeofint (talk) 02:48, 10 January 2017 (UTC)[reply]

^[1]

Content deleted from John Lawn page, mostly redundant but some may be integrated here

Role in the Criminalisation of MDMA

In January 1984, worried about increasing recreational use of MDMA, the DEA prepared a document for scheduling MDMA as a Schedule I substance,^[2] a classification for drugs seen as having a high potential for abuse and having no accepted medical use. Because MDMA was already in widespread use by psychiatrists, a group of psychiatrists and their lawyer filed a request for a hearing. The request was granted, although MDMA was scheduled on an emergency basis by the DEA before the hearings were heard anyway.^[3] On the basis of multiple witnesses testifying that there were medically accepted uses of MDMA in treatment, the administrative law judge in charge of the hearing, Francis L. Young recommended that MDMA be classified as Schedule III, a scheduling that many researchers, including Alexander Shulgin were willing to accept. However Lawn disagreed with the recommendation and ultimately MDMA was scheduled as Schedule I. The events were later echoed in 1988 when Lawn again overruled Justice Young who recommended for the reclassification of marijuana from Schedule I to Schedule III.

However, in 1987 the Harvard psychiatrist Dr. Lester Grinspoon sued the DEA, and the federal court sided with Grinspoon, calling Lawn's argument "strained" and "unpersuasive",^[4] and MDMA was unscheduled. However, less than a month later Lawn claimed that he had reconsidered the evidence and again classified MDMA as Schedule I. In his ruling Lawn claimed that evidence psychiatrists gave that they had administered MDMA to approximately 200 patients with positive effects should be dismissed as "merely anecdotal" as they were not published in medical journals.

The following has some useful references but I think it is redundant with current content and too loose on efficacy. Sizeofint (talk) 20:37, 18 May 2017 (UTC)[reply]

MDMA is known to improve sociability, friendliness, extroversion, to increase empathy and feelings of closeness with others, and to reduce interpersonal defensiveness.^{[1][2][3][4][5]} These effects are relevant to people with social anxiety and a group of researchers find that MDMA has therapeutic benefits for alleviating social anxiety.^[6][7][8]

Why do you think this content which is humanizing straight research is redundant?--TMCk (talk) 02:35, 19 May 2017 (UTC)[reply]

We already have a section on effects. I don't think it is necessary to repeat them in the research section. "A group of researchers find that MDMA has therapeutic benefits for alleviating social anxiety" has some weasel wording issues (which group?). Additionally, at least one of the sources was a bit more nuanced (I haven't closely examined the others yet) with the authors saying it "may" have therapeutic benefit, not that they believe it certainly does as this wording implies. Sizeofint (talk) 06:33, 19 May 2017 (UTC)[reply]

With respect to the sentence – "MDMA is known to improve sociability, friendliness, extroversion, to increase empathy and feelings of closeness with others, and to reduce interpersonal defensiveness.^{[1][2][3][4][5]}" – WP:MEDRS sources are required since these are clinical claims of drug effects. Among the cited refs, only this ref^[3] is a MEDRS-compliant source (i.e., a medical review). In any event, if others think that this is worth covering, I don't think that it should be too difficult to find other reviews that cover the effects that aren't supported by the cited review. There's plenty of medical sources which state that amphetamine increases sociability and self-expression, so MDMA is not unique in that regard. The non-empathogenic effects of MDMA on social behavior are likely derived from its amphetamine-like dopaminergic effects. Seppi333 (Insert 2¢) 09:01, 19 May 2017 (UTC)[reply]

Section references

Neither of the two provided sources actually support this weird statement. The first suggests that MDMA should be removed from its "no medical use" status and the other says that its use for therapeutic use is rare these days. --86.50.81.67 (talk) 02:41, 23 May 2017 (UTC)[reply]

If the authors are arguing its status should be changed then it currently must have no accepted medical use. Sizeofint (talk) 04:14, 23 May 2017 (UTC)[reply]

I agree with Sizeofint. The lack of medical indications logically follows from the fact that it has "no medical uses"; in any event, the source that was recently added to that sentence explicitly states this. Seppi333 (Insert 2¢) 18:55, 23 May 2017 (UTC)[reply]

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"There are numerous methods available in the literature to synthesize MDMA via different intermediates.[98][99][100][101]" seems this sentence is worded very poorly. It's redundant, essentially stating "There are many ways to make MDA" twice. I also don't think it needs the qualifier "in literature". I think a better sentence might be "There are numerous methods available to synthesize MDMA.[98][99][100][101]"

--173.66.69.186 (talk) 01:56, 26 August 2017 (UTC)[reply]

I think the 'different intermediates' portion is to emphasize the different precursors (safrole, isosafrol, etc.). The "in literature" part can be cut. Sizeofint (talk) 08:15, 26 August 2017 (UTC)[reply]

I had this crazy idea... How come people don't tell the truth and save everyone of the troubles arising from lies. Like: Mdma is extracted from sea shells... plain and simple.

• see also cocaine from ivory

Rgb.trouw (talk) 00:26, 8 September 2017 (UTC)[reply]