Cannabis Ruderalis

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== hyponatremia not hyponatraemia ==

I think it should be hyponatremia not hyponatraemia in "A scheme for management of acute MDMA toxicity has been published focusing on treatment of hyperthermia, hyponatraemia, serotonin syndrome, and multiple organ failure" but the reference does state hyponatraemia not https://en.wikipedia.org/wiki/Hyponatremia so not sure what is hyponatraemia is it on Wikipedia? <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:InGearX|InGearX]] ([[User talk:InGearX#top|talk]] • [[Special:Contributions/InGearX|contribs]]) 04:37, 7 October 2020 (UTC)</small> <!--Autosigned by SineBot-->


== Edit request 19 July 2023 ==


"Endogenous" is used in the introduction. It's neither linked nor defined. It's a $5 word. A $0.50 word would be better. Failing that, it would be helpful if it were a link to something - Wiktionary or an appropriate Wikipedia page. Thanks! [[Special:Contributions/108.64.118.44|108.64.118.44]] ([[User talk:108.64.118.44|talk]]) 00:48, 20 July 2023 (UTC)
== Heart risk research? ==
:{{done}} --[[User:WikiLinuz|<span style="font-family:Optima;color:#292928;">'''Wiki'''<span style="color:red;">'''''Linuz'''''</span></span>]] {[[User_talk:WikiLinuz|<span style="font-family:Optima;">talk</span>]]} 01:11, 20 July 2023 (UTC)


== The BP in a medium vacuum should not be listed ==
Could please anybody with a better judgment on medical topics than I have validate if this is a real adversarial risk:
https://thethirdwave.co/psychedelics-heart-risk/


The infobox currently lists the boiling point at 0.4 mmHg, which is a medium vacuum. It is not sourced, and it doesn't say whether this is the free base or what salt it is. This is nearly useless information and it isn't sourced, it should simply be removed. The melting points of the free base and any common salts, at atmospheric pressure, would be interesting data to add. Boiling point in a vacuum is silly. [[Special:Contributions/209.6.225.254|209.6.225.254]] ([[User talk:209.6.225.254|talk]]) 09:36, 24 November 2023 (UTC)
The cited study is:
https://www.ncbi.nlm.nih.gov/pubmed/19505264


== Is MDMA a psychedelic or not? ==
Apparently excessive MDMA exposure can lead to problems with activating the 5-HT2B receptor, which in turn could lead to heart valve problems.
This was new information to me, a lesser known potential side effect of MDMA use, I couldn't find it reflected in the current article. <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/2A02:168:F789:0:49CA:3E4F:ADBF:247F|2A02:168:F789:0:49CA:3E4F:ADBF:247F]] ([[User talk:2A02:168:F789:0:49CA:3E4F:ADBF:247F#top|talk]]) 11:40, 31 December 2019 (UTC)</small> <!--Autosigned by SineBot-->
:The mechanism in question here seems to be fairly well studied and is probably valid. They primarily cite [http://molpharm.aspetjournals.org/content/63/6/1223.short this study] which claims a preferential 5-HT<sub>2B</sub> binding of MDA and MDMA... they then go on to say that MDA is primarily responsible for the high binding as an active metabolite and say that it is a "very potent" agonist. No values are listed for MDA. From [https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.13128 this article], MDMA itself is effectively inactive at 5-HT<sub>2B</sub> (>20,000nm), and MDA is measured at a ~850nM / 52% efficacy which is very roughly half that of (+)-Fenfluramine and not even in the same universe as (+)-Norfenfluramine... and that's for one of the two possible MDMA metabolites barring any of the original drug that's excreted.<br/><br/>Since the VHD issue had already been noted in the prescription medications they studied, presumably the point of mentioning MDMA at all was to bring up another less studied drug that had potential to cause VHD and preliminary data from other studies suggesting that MDMA <i>might</i> provide another study point (as well as an explanation of that) but even the authors conclude with, ''"Finally, the observation that MDMA may produce VHD deserves additional study, as this adverse effect may ultimately cause greater morbidity than the widely studied effects of MDMA on brain function."'' I'd want a more recent / direct study of this specific effect to take it seriously although I don't think the logic of this research paper is incorrect. [[User:A Shortfall Of Gravitas|A Shortfall Of Gravitas]] ([[User talk:A Shortfall Of Gravitas|talk]]) 02:33, 23 January 2020 (UTC)


The best source for this claim is that there may be 5HT2A agonism, which "supposedly contributes" to "mild psychedelic hallucinations" caused by "high doses" of MDMA. That's a lot of words to say that its status as a psychedelic is pretty flimsy.
== Semi-protected edit request on 31 December 2019 ==


The other sources don't support that it is one, either, just that it's commonly referred to as one. This is similar to how cocaine is called a "narcotic," a legal stipulative definition that's quite different from the scientific one.
{{edit semi-protected|MDMA|answered=yes}}
Under the headline "Adverse effects" and sub-headline "Long-term" in the first paragraph, the acronym "SERT" is used for the first time in the article without explaining what it means. A link should be added to the corresponding Wikipedia page and a parenthesis should be added after "SERT", so the text reads "...moderate to severe effects for [[Serotonin transporter|SERT]] (serotonin transporter) reduction. [[User:Asbjoern o|Asbjoern o]] ([[User talk:Asbjoern o|talk]]) 12:25, 31 December 2019 (UTC)
:[[File:Yes check.svg|20px|link=|alt=]] '''Done'''<!-- Template:ESp --> – '''[[User:Þjarkur|Thjarkur]]''' [[User talk:Þjarkur|(talk)]] 15:02, 31 December 2019 (UTC)


I'm not arguing that MDMA isn't a psychedelic, but if these are the best sources we have I think it should be removed from the lead. [[Special:Contributions/2600:1017:B103:D814:CCC9:7381:FFDB:5A2D|2600:1017:B103:D814:CCC9:7381:FFDB:5A2D]] ([[User talk:2600:1017:B103:D814:CCC9:7381:FFDB:5A2D|talk]]) 17:51, 13 December 2023 (UTC)
== Source for addiction as a possible effect ==


:MDMA is not in any way, shape or form, a ''classic psychedelic'', meaning that it cannot be directly compared to [[LSD]], [[psilocybin]], or even [[mescaline]], but it ''is'' somewhat closer to mescaline than many other things that people consider to have psychedelic properties, such as [[cannabis]], [[ketamine]], [[salvia divinorum]], and even [[muscimol]]. The lead says it has "minor psychedelic properties", but that doesn't mean that it ''is'' a psychedelic. Perhaps we just need some clarification in the lead that while it has ''minor psychedelic properties'', it is not technically a psychedelic. [[User:Thoric|Thoric]] ([[User talk:Thoric|talk]]) 18:35, 13 December 2023 (UTC)
I removed addiction as a possible effect of MDMA and got reverted. As I mentioned in my edit summary, the cited source only says the data regarding addictivity of MDMA is controversial. If no specific reason is provided for this being included, I'll remove it again. --[[User:UKER|uKER]] ([[User talk:UKER|talk]]) 18:17, 30 November 2020 (UTC)
:The statement in the lede was summarizing the entire article, not just that single ref. I have removed it for that reason. [[User:Alexbrn|Alexbrn]] ([[User talk:Alexbrn|talk]]) 18:32, 30 November 2020 (UTC)


== MDMA addiction/dependence ==
== Bruxism → Chewing Gum? ==


Should we add that some users chew gum in order to deal with grinding teeth? Since the article is semi-protected, I wanted to check before just adding it in (especially since finding a good source for this is trickier than I though). [[User:Niplav|Niplav]] ([[User talk:Niplav|talk]]) 13:57, 7 February 2024 (UTC)
Could someone who understands DSM-IV classification and terminology check the rates of MDMA "abuse" and "dependence" (I'm not sure what is the difference between these terms). This MDMA article [https://en.wikipedia.org/w/index.php?title=MDMA&oldid=992997931 currently] states "One study found approximately 15% of chronic MDMA users met the DSM-IV diagnostic criteria for substance dependence." This citation is based on this {{Pmid|19893331}} study, which claims within the abstract "One fifth of the participants were screened as potentially dependent." 1/5 is 20%, not 15%. Also, why does this {{PMC|2891907}} study claim within table 1 that, according to DSM-IV classification, MDMA has "abuse" rates between 4.4-11.2% and "dependence" rates between 44.6-66.4% (way higher that "15%"). Latter is extremely high and DSM-IV clearly defines the word "dependence" in some other way than a psychology layman like me.


== The role of Danny Leclère in the production of XTC as partydrug ==
Additionally, substance addiction/dependence/use disorder/abuse (whatever is the difference between these terms, I dunno?) is a complex issue, it might be better to have aggregated rates for these % estimates from multiple studies so that the rates would be more valid internationally speaking instead of citing the results of a single study. [[User:5-HT2AR|5-HT2AR]] ([[User talk:5-HT2AR|talk]]) 12:06, 12 December 2020 (UTC)


I have a proposition to add some text regarding [[Danny Leclère]] who developed in the 1990's a formula to produce "pure XTC" as party drug and set up a worldwide illegal network to have the drugs distributed. It's because if him XTC became popular in nightlife. The formula of Leclère is still the most used in the manufacturing of (illegal) XTC. Valid/Trusted references can be found in the article about [[Danny Leclère]]. I think a short topic in the article of MDMA is advisable due to Leclère his role in production/distribution of illegal XTC. [[User:Ino mart|Ino mart]] ([[User talk:Ino mart|talk]]) 15:31, 6 March 2024 (UTC)
== Names for different combinations of MDMA + other drugs ==


:is "pure XTC" MDMA? [[User:Bon courage|Bon courage]] ([[User talk:Bon courage|talk]]) 15:55, 6 March 2024 (UTC)
In the article, the combination of MDMA with LSD, psilocybin mushrooms or ketamine are all given the name "candy-flip". However, from experience on forums and such I have gathered that MDMA + LSD = Candy Flip, MDMA + psilocybin = Hippy Flip and MDMA + ketamine = Kitty Flip. Unfortunately I do not have concrete sources, since this is something I have encountered so often that listing all instances would be impossible, howeve the main forum I have encountered these names at is Reddit.com
::According the documentary "Bad, Bad Belgium" the term "pure XTC" refers to the formula by Leclère: it is the first XTC-formula which only contains MDMA as drug. At that time, MDMA-drugs also contained other ingredients such as meta-Chlorophenylpiperazine and para-Methoxy-N-methylamphetamine.

Revision as of 23:15, 19 March 2024


Edit request 19 July 2023

"Endogenous" is used in the introduction. It's neither linked nor defined. It's a $5 word. A $0.50 word would be better. Failing that, it would be helpful if it were a link to something - Wiktionary or an appropriate Wikipedia page. Thanks! 108.64.118.44 (talk) 00:48, 20 July 2023 (UTC)[reply]

 Done --WikiLinuz {talk} 01:11, 20 July 2023 (UTC)[reply]

The BP in a medium vacuum should not be listed

The infobox currently lists the boiling point at 0.4 mmHg, which is a medium vacuum. It is not sourced, and it doesn't say whether this is the free base or what salt it is. This is nearly useless information and it isn't sourced, it should simply be removed. The melting points of the free base and any common salts, at atmospheric pressure, would be interesting data to add. Boiling point in a vacuum is silly. 209.6.225.254 (talk) 09:36, 24 November 2023 (UTC)[reply]

Is MDMA a psychedelic or not?

The best source for this claim is that there may be 5HT2A agonism, which "supposedly contributes" to "mild psychedelic hallucinations" caused by "high doses" of MDMA. That's a lot of words to say that its status as a psychedelic is pretty flimsy.

The other sources don't support that it is one, either, just that it's commonly referred to as one. This is similar to how cocaine is called a "narcotic," a legal stipulative definition that's quite different from the scientific one.

I'm not arguing that MDMA isn't a psychedelic, but if these are the best sources we have I think it should be removed from the lead. 2600:1017:B103:D814:CCC9:7381:FFDB:5A2D (talk) 17:51, 13 December 2023 (UTC)[reply]

MDMA is not in any way, shape or form, a classic psychedelic, meaning that it cannot be directly compared to LSD, psilocybin, or even mescaline, but it is somewhat closer to mescaline than many other things that people consider to have psychedelic properties, such as cannabis, ketamine, salvia divinorum, and even muscimol. The lead says it has "minor psychedelic properties", but that doesn't mean that it is a psychedelic. Perhaps we just need some clarification in the lead that while it has minor psychedelic properties, it is not technically a psychedelic. Thoric (talk) 18:35, 13 December 2023 (UTC)[reply]

Bruxism → Chewing Gum?

Should we add that some users chew gum in order to deal with grinding teeth? Since the article is semi-protected, I wanted to check before just adding it in (especially since finding a good source for this is trickier than I though). Niplav (talk) 13:57, 7 February 2024 (UTC)[reply]

The role of Danny Leclère in the production of XTC as partydrug

I have a proposition to add some text regarding Danny Leclère who developed in the 1990's a formula to produce "pure XTC" as party drug and set up a worldwide illegal network to have the drugs distributed. It's because if him XTC became popular in nightlife. The formula of Leclère is still the most used in the manufacturing of (illegal) XTC. Valid/Trusted references can be found in the article about Danny Leclère. I think a short topic in the article of MDMA is advisable due to Leclère his role in production/distribution of illegal XTC. Ino mart (talk) 15:31, 6 March 2024 (UTC)[reply]

is "pure XTC" MDMA? Bon courage (talk) 15:55, 6 March 2024 (UTC)[reply]
According the documentary "Bad, Bad Belgium" the term "pure XTC" refers to the formula by Leclère: it is the first XTC-formula which only contains MDMA as drug. At that time, MDMA-drugs also contained other ingredients such as meta-Chlorophenylpiperazine and para-Methoxy-N-methylamphetamine.

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