Cannabis Ruderalis

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== Source for addiction as a possible effect ==

I removed addiction as a possible effect of MDMA and got reverted. As I mentioned in my edit summary, the cited source only says the data regarding addictivity of MDMA is controversial. If no specific reason is provided for this being included, I'll remove it again. --[[User:UKER|uKER]] ([[User talk:UKER|talk]]) 18:17, 30 November 2020 (UTC)
:The statement in the lede was summarizing the entire article, not just that single ref. I have removed it for that reason. [[User:Alexbrn|Alexbrn]] ([[User talk:Alexbrn|talk]]) 18:32, 30 November 2020 (UTC)

== MDMA addiction/dependence ==

Could someone who understands DSM-IV classification and terminology check the rates of MDMA "abuse" and "dependence" (I'm not sure what is the difference between these terms). This MDMA article [https://en.wikipedia.org/w/index.php?title=MDMA&oldid=992997931 currently] states "One study found approximately 15% of chronic MDMA users met the DSM-IV diagnostic criteria for substance dependence." This citation is based on this {{Pmid|19893331}} study, which claims within the abstract "One fifth of the participants were screened as potentially dependent." 1/5 is 20%, not 15%. Also, why does this {{PMC|2891907}} study claim within table 1 that, according to DSM-IV classification, MDMA has "abuse" rates between 4.4-11.2% and "dependence" rates between 44.6-66.4% (way higher that "15%"). Latter is extremely high and DSM-IV clearly defines the word "dependence" in some other way than a psychology layman like me.

Additionally, substance addiction/dependence/use disorder/abuse (whatever is the difference between these terms, I dunno?) is a complex issue, it might be better to have aggregated rates for these % estimates from multiple studies so that the rates would be more valid internationally speaking instead of citing the results of a single study. [[User:5-HT2AR|5-HT2AR]] ([[User talk:5-HT2AR|talk]]) 12:06, 12 December 2020 (UTC)

== Names for different combinations of MDMA + other drugs ==

In the article, the combination of MDMA with LSD, psilocybin mushrooms or ketamine are all given the name "candy-flip". However, from experience on forums and such I have gathered that MDMA + LSD = Candy Flip, MDMA + psilocybin = Hippy Flip and MDMA + ketamine = Kitty Flip. Unfortunately I do not have concrete sources, since this is something I have encountered so often that listing all instances would be impossible, however the main forum I have encountered these names at is Reddit.com


== Edit request 19 July 2023 ==
== Name ==
The phrase "commonly known as ecstasy (E) or molly" is misleading, given the reported increasing adulteration of illegally marketed drugs termed "ecstasy", which are likely to be "enhanced" with ketamine, caffeine, BZP, and other narcotics and stimulants.


"Endogenous" is used in the introduction. It's neither linked nor defined. It's a $5 word. A $0.50 word would be better. Failing that, it would be helpful if it were a link to something - Wiktionary or an appropriate Wikipedia page. Thanks! [[Special:Contributions/108.64.118.44|108.64.118.44]] ([[User talk:108.64.118.44|talk]]) 00:48, 20 July 2023 (UTC)
I suggest a cautionary description would be better, i.e. "3,4-Methyl​enedioxy​methamphetamine (MDMA),[note 1] is a psychoactive drug primarily used for recreational purposes.[13] Drugs distributed as "ecstasy (E) or molly" are normally purported to contain MDMA, but are often adulterated by ketamine, caffeine, BZP, and other narcotics and stimulants." <!-- Template:Unsigned --><span class="autosigned" style="font-size:85%;">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Carusus|Carusus]] ([[User talk:Carusus#top|talk]] • [[Special:Contributions/Carusus|contribs]]) 14:31, 10 February 2021 (UTC)</span> <!--Autosigned by SineBot-->
:{{done}} --[[User:WikiLinuz|<span style="font-family:Optima;color:#292928;">'''Wiki'''<span style="color:red;">'''''Linuz'''''</span></span>]] {[[User_talk:WikiLinuz|<span style="font-family:Optima;">talk</span>]]} 01:11, 20 July 2023 (UTC)


== The BP in a medium vacuum should not be listed ==
== Evidence for PTSD efficacy ==


The infobox currently lists the boiling point at 0.4 mmHg, which is a medium vacuum. It is not sourced, and it doesn't say whether this is the free base or what salt it is. This is nearly useless information and it isn't sourced, it should simply be removed. The melting points of the free base and any common salts, at atmospheric pressure, would be interesting data to add. Boiling point in a vacuum is silly. [[Special:Contributions/209.6.225.254|209.6.225.254]] ([[User talk:209.6.225.254|talk]]) 09:36, 24 November 2023 (UTC)
{{SPER}}


== Is MDMA a psychedelic or not? ==
The research section currently states:


The best source for this claim is that there may be 5HT2A agonism, which "supposedly contributes" to "mild psychedelic hallucinations" caused by "high doses" of MDMA. That's a lot of words to say that its status as a psychedelic is pretty flimsy.
''MDMA has been claimed to be useful in treating post-traumatic stress disorder, but such claims are not backed by good evidence.[181]''


The other sources don't support that it is one, either, just that it's commonly referred to as one. This is similar to how cocaine is called a "narcotic," a legal stipulative definition that's quite different from the scientific one.
Source 181 actually states:


I'm not arguing that MDMA isn't a psychedelic, but if these are the best sources we have I think it should be removed from the lead. [[Special:Contributions/2600:1017:B103:D814:CCC9:7381:FFDB:5A2D|2600:1017:B103:D814:CCC9:7381:FFDB:5A2D]] ([[User talk:2600:1017:B103:D814:CCC9:7381:FFDB:5A2D|talk]]) 17:51, 13 December 2023 (UTC)
''It has been suggested that MDMA, for example, possesses characteristics that make it uniquely useful for the treatment of PTSD [122]; the same has been argued for ibogaine in the treatment of SUD [42]. The high heterogeneity of the articles included in this review do not provide sufficient evidence to establish these relations''


:MDMA is not in any way, shape or form, a ''classic psychedelic'', meaning that it cannot be directly compared to [[LSD]], [[psilocybin]], or even [[mescaline]], but it ''is'' somewhat closer to mescaline than many other things that people consider to have psychedelic properties, such as [[cannabis]], [[ketamine]], [[salvia divinorum]], and even [[muscimol]]. The lead says it has "minor psychedelic properties", but that doesn't mean that it ''is'' a psychedelic. Perhaps we just need some clarification in the lead that while it has ''minor psychedelic properties'', it is not technically a psychedelic. [[User:Thoric|Thoric]] ([[User talk:Thoric|talk]]) 18:35, 13 December 2023 (UTC)
This is not the same thing. The study does not claim that the evidence of usefulness is limited, but that the evidence for ''unique'' usefulness is limited.


== Bruxism → Chewing Gum? ==
Moreover, a [https://pubmed.ncbi.nlm.nih.gov/32931403/ newer review] that is more specific to the topic and includes more trials states the following:


Should we add that some users chew gum in order to deal with grinding teeth? Since the article is semi-protected, I wanted to check before just adding it in (especially since finding a good source for this is trickier than I though). [[User:Niplav|Niplav]] ([[User talk:Niplav|talk]]) 13:57, 7 February 2024 (UTC)
''The evidence for MDMA in combination with psychotherapy as a PTSD treatment was ranked "moderate"''


== The role of Danny Leclère in the production of XTC as partydrug ==
I propose that the last sentence in the research section states:


I have a proposition to add some text regarding [[Danny Leclère]] who developed in the 1990's a formula to produce "pure XTC" as party drug and set up a worldwide illegal network to have the drugs distributed. It's because if him XTC became popular in nightlife. The formula of Leclère is still the most used in the manufacturing of (illegal) XTC. Valid/Trusted references can be found in the article about [[Danny Leclère]]. I think a short topic in the article of MDMA is advisable due to Leclère his role in production/distribution of illegal XTC. [[User:Ino mart|Ino mart]] ([[User talk:Ino mart|talk]]) 15:31, 6 March 2024 (UTC)
''MDMA in combination with psychotherapy has been studied as a treatment for PTSD, and four clinical trials provide moderate evidence in support of this''


[[User:Juniusbrutus|Juniusbrutus]] ([[User talk:Juniusbrutus|talk]]) 04:10, 21 February 2021 (UTC)
:is "pure XTC" MDMA? [[User:Bon courage|Bon courage]] ([[User talk:Bon courage|talk]]) 15:55, 6 March 2024 (UTC)
::According the documentary "Bad, Bad Belgium" the term "pure XTC" refers to the formula by Leclère: it is the first XTC-formula which only contains MDMA as drug. At that time, MDMA-drugs also contained other ingredients such as meta-Chlorophenylpiperazine and para-Methoxy-N-methylamphetamine.

Revision as of 23:15, 19 March 2024


Edit request 19 July 2023

"Endogenous" is used in the introduction. It's neither linked nor defined. It's a $5 word. A $0.50 word would be better. Failing that, it would be helpful if it were a link to something - Wiktionary or an appropriate Wikipedia page. Thanks! 108.64.118.44 (talk) 00:48, 20 July 2023 (UTC)[reply]

 Done --WikiLinuz {talk} 01:11, 20 July 2023 (UTC)[reply]

The BP in a medium vacuum should not be listed

The infobox currently lists the boiling point at 0.4 mmHg, which is a medium vacuum. It is not sourced, and it doesn't say whether this is the free base or what salt it is. This is nearly useless information and it isn't sourced, it should simply be removed. The melting points of the free base and any common salts, at atmospheric pressure, would be interesting data to add. Boiling point in a vacuum is silly. 209.6.225.254 (talk) 09:36, 24 November 2023 (UTC)[reply]

Is MDMA a psychedelic or not?

The best source for this claim is that there may be 5HT2A agonism, which "supposedly contributes" to "mild psychedelic hallucinations" caused by "high doses" of MDMA. That's a lot of words to say that its status as a psychedelic is pretty flimsy.

The other sources don't support that it is one, either, just that it's commonly referred to as one. This is similar to how cocaine is called a "narcotic," a legal stipulative definition that's quite different from the scientific one.

I'm not arguing that MDMA isn't a psychedelic, but if these are the best sources we have I think it should be removed from the lead. 2600:1017:B103:D814:CCC9:7381:FFDB:5A2D (talk) 17:51, 13 December 2023 (UTC)[reply]

MDMA is not in any way, shape or form, a classic psychedelic, meaning that it cannot be directly compared to LSD, psilocybin, or even mescaline, but it is somewhat closer to mescaline than many other things that people consider to have psychedelic properties, such as cannabis, ketamine, salvia divinorum, and even muscimol. The lead says it has "minor psychedelic properties", but that doesn't mean that it is a psychedelic. Perhaps we just need some clarification in the lead that while it has minor psychedelic properties, it is not technically a psychedelic. Thoric (talk) 18:35, 13 December 2023 (UTC)[reply]

Bruxism → Chewing Gum?

Should we add that some users chew gum in order to deal with grinding teeth? Since the article is semi-protected, I wanted to check before just adding it in (especially since finding a good source for this is trickier than I though). Niplav (talk) 13:57, 7 February 2024 (UTC)[reply]

The role of Danny Leclère in the production of XTC as partydrug

I have a proposition to add some text regarding Danny Leclère who developed in the 1990's a formula to produce "pure XTC" as party drug and set up a worldwide illegal network to have the drugs distributed. It's because if him XTC became popular in nightlife. The formula of Leclère is still the most used in the manufacturing of (illegal) XTC. Valid/Trusted references can be found in the article about Danny Leclère. I think a short topic in the article of MDMA is advisable due to Leclère his role in production/distribution of illegal XTC. Ino mart (talk) 15:31, 6 March 2024 (UTC)[reply]

is "pure XTC" MDMA? Bon courage (talk) 15:55, 6 March 2024 (UTC)[reply]
According the documentary "Bad, Bad Belgium" the term "pure XTC" refers to the formula by Leclère: it is the first XTC-formula which only contains MDMA as drug. At that time, MDMA-drugs also contained other ingredients such as meta-Chlorophenylpiperazine and para-Methoxy-N-methylamphetamine.

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