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| Formula | C24H31FN2O |
| Molar mass | 382.51 g/mol g·mol−1 |
STS-135 (N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide, also called 5F-APICA) is a designer drug offered by online vendors as a cannabimimetic agent. The structure of STS-135 appears to utilise an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear.[1] STS-135 is the terminally-fluorinated analogue of SDB-001, just as AM-2201 is the terminally-fluorinated analogue of JWH-018, and XLR-11 is the terminally-fluorinated analogue of UR-144. STS-135 acts a potent cannabinoid receptor agonist in vitro, with an EC50 of 51 nM for human CB2 receptors, and 13 nM for human CB1 receptors.[2] STS-135 produces bradycardia and hypothermia in rats at doses of 1-10 mg/kg, suggesting cannabinoid-like activity.[2]
Detection
A forensic standard of STS-135 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[3]
See also
References
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|doi=10.1071/CH14198instead. - ^ a b Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1021/acschemneuro.5b00107, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with
|doi=10.1021/acschemneuro.5b00107instead. - ^ Southern Association of Forensic Scientists